Karen was just outside the door, and, seeing as this was a typical suburban home and not some kind of impenetrable fortress of solitude, she heard everything the men (and a few new women) had said. Worse than that, she knew exactly what the boys had on their minds and while a little bit of lesbian affection was the purpose of the powder (why else would it have the ability to transform people?) and so too was sexual experimentation (please see above) it was also clear that these high school males probably had no objection to violating the new females sexual orientation (among other, much more physical aspects). She had only one idea of what they were thinking and it wasn't that they were going to play an innocent game of twister with the girls.
And judging from how quickly the first two had been dosed, it wouldn't take long before all of them would be involved. She needed help.